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Author Ping, Peipei ♦ Zhang, Jun ♦ Huang, Shuang ♦ Cao, Xinan ♦ Tang, Xian-Liang ♦ Li, Richard C. X. ♦ Zheng, Yu-Ting ♦ Qiu, Yumin ♦ Clerk, Angela ♦ Sugden, Peter ♦ Han, Jiahuai ♦ Bolli, Roberto
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Ischemic Preconditioning ♦ P46 P54 Jnks ♦ Conscious Rabbit ♦ H1771 H1785 ♦ Pkc-dependent Activation ♦ Physiol Heart Circ Physiol ♦ Protein Kinase ♦ Conscious Rabbit Model ♦ Surgical Trauma ♦ 4-min Ischemia 4-min Reperfusion ♦ Adult Rabbit Cardiac Myocytes ♦ Pkc Activity ♦ External Stress ♦ Stress-activated Kinase C-jun Nh2-terminal Kinase ♦ Heart Circ ♦ P46 Jnk ♦ Vitro Evidence ♦ Environment Free ♦ Pkc Inhibitor Chelerythrine ♦ Significant Activation ♦ Ischemic Pc ♦ Cytosolic Fraction ♦ Nuclear Fraction ♦ Particulate Fraction ♦ Enhanced Activity ♦ P54 Jnk ♦ Selective Enhancement
Abstract JNKs during ischemic preconditioning in conscious rabbits. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1771–H1785, 1999.—A conscious rabbit model was used to study the effect of ischemic preconditioning (PC) on stress-activated kinases [c-Jun NH2-terminal kinases (JNKs) and p38 mitogenactivated protein kinase (MAPK)] in an environment free of surgical trauma and attending external stress. Ischemic PC (6 cycles of 4-min ischemia/4-min reperfusion) induced significant activation of protein kinase C (PKC)- � in the particulate fraction, which was associated with activation of p46 JNK in the nuclear fraction and p54 JNK in the cytosolic fraction; all of these changes were completely abolised by the PKC inhibitor chelerythrine. Selective enhancement of PKC- � activity in adult rabbit cardiac myocytes resulted in enhanced activity of p46/p54 JNKs, providing direct in vitro evidence
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 1999-01-01