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Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Inhibitory Function ♦ Mouse Model ♦ Macrophage Fcriib ♦ First Time Fcriib Protein Expression ♦ Great Importance ♦ Human Monocyte ♦ Down-regulate Fcr-mediated Phago-cytosis ♦ Immune Complex-induced Inflammation ♦ Hu-man Monocyte ♦ Fcriib Expression ♦ Th2 Cytokine ♦ Cytotoxic Antibody
Abstract expression and function of these receptors has been ex-tensively studied with the exception of one, FcRIIb. While the mRNA for FcRIIb has been detected in hu-man monocytes, the protein has remained elusive. Stud-ies in mouse models indicated that the macrophage FcRIIb serves to down-regulate FcR-mediated phago-cytosis and immune complex-induced inflammation. FcRIIb has also been shown to modulate the action of cytotoxic antibodies against tumors in mouse models. Hence, an understanding of how FcRIIb expression is regulated is of great importance. Here we demonstrate for the first time FcRIIb protein expression and func-tion in human monocytes. We also report that the ex-pression of FcRIIb is highly up-regulated by interleu-kin-4, a Th2 cytokine, and that the up-regulation of
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 2001-01-01