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Author Conrad, Emery D. ♦ Phillips, John ♦ Renardy, Michael
Source CiteSeerX
Content type Text
File Format PDF
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Physiological Process ♦ Complex Regulatory Network ♦ Biology Better ♦ Good Job ♦ Circadian Clock ♦ Temperature Signal ♦ Future Experiment ♦ Cycling Environment ♦ Predictable Manner ♦ Trivial Task ♦ Constant Condition ♦ Molecular Mechanism ♦ Bifurcation Analysis ♦ Or-ganism Interaction ♦ Circadian Rhythm ♦ Basal Period ♦ Qualitative Optimization ♦ Cell-autonomous Oscillator ♦ Negative Feed-back Loop Interact ♦ Mathematical Modeling ♦ Large Range ♦ Molecular Cell Biology ♦ Actual Biological System ♦ Useful Tool ♦ External Light ♦ 24-hour Rhythm ♦ Many Different Specie
Description Institute and State University
Circadian rhythms are the endogenous, roughly 24-hour rhythms that coordinate an or-ganism’s interaction with its cycling environment. The molecular mechanism underlying this physiological process is a cell-autonomous oscillator comprised of a complex regulatory network of interacting DNA, RNA and proteins that is surprisingly conserved across many different species. It is not a trivial task to understand how the positive and negative feed-back loops interact to generate an oscillator capable of a) maintaining a 24-hour rhythm in constant conditions; b) entraining to external light and temperature signals; c) responding to pulses of light in a rather particular, predictable manner; and d) compensating itself so that the period is relatively constant over a large range of temperatures, even for mutations that affect the basal period of oscillation. Mathematical modeling is a useful tool for dealing with such complexity, because it gives us an object that can be quickly probed and tested in lieu of the experiment or actual biological system. If we do a good job designing the model, it will help us to understand the biology better by predicting the outcome of future experiments. The difficulty lies in
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article