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Author Shengjun, Wang ♦ Yunbo, Guo ♦ Liyan, Song ♦ Jinming, Li ♦ Qinkai, Deng
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Nasopharyngeal Carcinoma ♦ Therapeutic Effect ♦ Research Open Access Quantitative Study ♦ Cytotoxic T-lymphocyte Immunotherapy ♦ Intravenous Injection ♦ Treatment Time-points ♦ Increment Rate ♦ Laboratory Research ♦ Tumor Cell Cytomembrane ♦ Undifferentiated Nasopharyngeal Carcinoma ♦ Phosphorylated Transforming Growth ♦ Ebv Lmp2-specific Ctl ♦ Corresponding Therapeutic Effect ♦ Different Treatment Time-points ♦ Different Ctl Specificity ♦ Epidermal Growth Factor Receptor ♦ Cytotoxic T-lymphocyte ♦ Common Strategy ♦ Background Epstein-barr Virus ♦ Treatment Time-point ♦ Viral Antigen ♦ Mathematical Model ♦ Total Number ♦ Tumor Pro-vide Potential Target ♦ Ctl Immunotherapy ♦ Tumor Cell Cytomembrane Increase ♦ Simulation Result ♦ Marked Downward Trend ♦ Line Several Time ♦ Restricted Set ♦ Clinical Practice ♦ Tumor Growth ♦ Tumor Cell ♦ Article Background ♦ Egfr Complex
Abstract available at the end of the article Background: In clinical practice, the common strategy for immunotherapy of nasopharyngeal carcinoma (NPC) is to infuse cytotoxic T-lymphocyte (CTL) lines several times by intravenous injection, but it is difficult by laboratory research to investigate the relationship between treatment time-point, the amount of CTL added and the therapeutic effect. The objective of this study is to establish a mathematical model to study the therapeutic effect of different treatment time-points and amounts of CTL, and to predict the change in therapeutic effect when the percentage of EBV LMP2-specific CTL is increased from 10 % to 20%. Results: The concentration of epidermal growth factor receptor (EGFR) in the tumor cell cytomembranes increases after CTL is added. Concurrently, there is a marked downward trend of the phosphorylated transforming growth factor-a (TGFa)-EGFR complex in the tumor cell cytomembranes, which indicates restriction of tumor growth after CTL immunotherapy. The relationships among the time of addition of CTL, the amount of CTL added, different CTL specificities for LMP2 and the increment rate k of the total number of tumor cells were evaluated. Conclusions: The simulation results quantify the relationships among treatment time-points, amount of CTL added, and the corresponding therapeutic effect of immunotherapy for NPC. Background Epstein-Barr virus is present in virtually all poorly-differentiated and undifferentiated nasopharyngeal carcinomas (NPC) and the viral antigens expressed by the tumor pro-vide potential targets for immunotherapy [1]. NPCs only express a restricted set of less
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article