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Author Stevensson, Baltzar ♦ Clas, L. ♦ Maliniak, Arnold
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Conformational Distribution Function ♦ Using Nmr Spectroscopy ♦ Liquid Crystalline Phase ♦ Considerable Time ♦ Complete Information ♦ Oversimplified Picture ♦ Nuclear Overhauser Effect ♦ Glycosidic Linkage ♦ Molecular Structure ♦ Show Conforma-tional Flexibility ♦ Dilute Liquid Crystalline Phase ♦ Molecular Conformation ♦ Molecular Property ♦ Nonspherical Solute Molecule ♦ Through-space Magnetic Dipole ♦ Torsion Angle ♦ Biological Function ♦ Single Molecular Structure ♦ Nucleic Acid ♦ Slight Net Orientation
Abstract Proteins, nucleic acids, and carbohydrates all show conforma-tional flexibility, but the extent is dependent on the structure and their environment. The motion in saccharides, in particular at the glycosidic linkage, defined by torsion angles and ª is of importance for molecular properties and biological function. Thus, the approximation of a single molecular structure is certainly an oversimplified picture. To obtain complete information about the molecular structure we desire to determine the conformational distribution function, P(,ª). Analysis of molecular conformations has for a considerable time relied on either the nuclear Overhauser effect (NOE), spin-spin (J) couplings, or a combination of these two. Recently, the application of dilute liquid crystalline phases (bicelles) as solvents enabled a slight net orientation of nonspherical “solute ” molecules and therefore determination of through-space magnetic dipole-
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 2002-01-01