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Author Duyn, Jeff H. ♦ Tan, Charlene X. ♦ Gelderen, Peter Van ♦ Yongbi, Martin N.
Source CiteSeerX
Content type Text
File Format PDF
Language English
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Overall Improvement ♦ Perfusion Sensitivity ♦ Twofold-improved Temporal Resolution ♦ High-sensitivity Single-shot Perfusion-weighted Fmri ♦ Background Signal ♦ Perfusion Change ♦ Activation-related Perfusion Change ♦ Back-ground Signal Fluctuation ♦ Twofold Increase ♦ Fair-type Perfusion ♦ Allowed Omission ♦ Double-inversion Labeling Strategy ♦ Motor Cortex Activation Study ♦ Signal Averaging ♦ Magn Re ♦ Single-shot Pulsed Spin Labeling Technique ♦ Perfusion Signal ♦ Brain Activation ♦ Stationary Tissue
Description A method is presented for measurement of perfusion changes during brain activation using a single-shot pulsed spin labeling technique. By employing a double-inversion labeling strategy, stationary tissue (background) signal was suppressed while minimally affecting perfusion sensitivity. This allowed omission of the otherwise required reference scan, resulting in twofold-improved temporal resolution. The method was applied to vi-sual and motor cortex activation studies in humans, and com-pared to standard FAIR-type perfusion labeling techniques. Ex-periments performed at 1.5T and 3.0T indicate a close to 90% suppression of background signal, at a cost of an 11 % and 9%, respectively, reduction in perfusion signal. Combined with the twofold increase in signal averaging, and a reduction in back-ground signal fluctuations, this resulted in a 64 % (1.5T, N 5 3) and a 128 % (3T, N 5 4) overall improvement in sensitivity for the detection of activation-related perfusion changes. Magn Re-
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2001-01-01
Journal Magnetic Resonance in Medicine