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Author Md, Ulrich Schweiger
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Visceral Fat ♦ Insulin Sensitivity ♦ Depressed Woman ♦ Without Comorbid Borderline Personality Disorder ♦ Visceral Fat Deposition ♦ Insulin Resistance ♦ Depressed Patient ♦ Healthy Woman ♦ Homeostasis Assessment Model ♦ Comorbid Bpd ♦ Twelve Bpd Patient ♦ Tumor Necrosis Factor Concentration ♦ Hypothalamic Pituitary Adrenal System ♦ Cardiovascular Disorder ♦ Major Depressive Disorder ♦ Ischemic Heart Disease ♦ Borderline Personality Disorder ♦ Risk Group ♦ Cell Sensitivity ♦ Comparison Group ♦ Noninsulin-dependent Diabetes ♦ Comorbid Bpd Display ♦ Woman Comorbid ♦ First Lumbar Vertebral Body ♦ Immune Dysregulation ♦ Premenopausal Woman ♦ Endocrine Alteration ♦ Important Antecedent ♦ Tumor Necrosis Factor ♦ Magnetic Resonance Tomography ♦ Comorbid Patient ♦ Data Support ♦ Increased Intra-abdominal Fat ♦ Young Depressed Woman ♦ Serum Concentration ♦ Metabolic Syndrome ♦ Reduced Insulin Sensitivity
Abstract Objective: Major depressive disorder (MDD) is associated with increased intra-abdominal fat, an important antecedent of noninsulin-dependent diabetes mellitus (NIDDM) and cardiovascular disorders. Furthermore, MDD is commonly accompanied by endocrine and immune dysregulation that has also been discussed in connection with the pathogenesis of NIDDM and ischemic heart disease. In borderline personality disorder (BPD), a dysregulation of the hypothalamic–pituitary–adrenal system has also been described. Therefore, our study aimed at examining visceral fat, insulin resistance, and alterations of cortisol and cytokines in young depressed women with and without comorbid BPD. Methods: Visceral fat was measured in 18 premenopausal women with MDD and in 18 women comorbid with MDD and BPD by means of magnetic resonance tomography at the level of the first lumbar vertebral body. Twelve BPD patients without MDD and 20 healthy women served as the comparison groups. Concentrations of fasting cortisol, tumor necrosis factor-, and interleukin-6 were measured, and indicators of insulin resistance and -cell sensitivity were calculated according to the homeostasis assessment model. Results:We found increased visceral fat in women comorbid with MDD and BPD, and to a lesser extent, in women with MDD but without BPD. Insulin sensitivity was reduced in comorbid patients. Serum interleukin-6 (IL-6) and tumor necrosis factor- concentrations were significantly increased in both groups of depressed patients. Reduced insulin sensitivity correlated with the amount of visceral fat and with serum concentrations of IL-6. Conclusion: Young depressed women with and without comorbid BPD display increased visceral fat and may constitute a risk group for the development of NIDDM and the metabolic syndrome. Our data support the hypothesis that the immune and endocrine alterations
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study