|Subject Domain (in DDC)||Computer science, information & general works ♦ Data processing & computer science|
|Subject Keyword||Thrombotic Thrombocytopenic ♦ Thrombotic Thrombocytopenic Purpura ♦ Systemic Lupus Erythematosus ♦ Cerebral Dysfunction ♦ Progressive Renal Failure ♦ Early Recognition ♦ Clinical Feature ♦ Case Report ♦ Immunosuppressive Treatment ♦ Literature Review Thrombotic Thrombocytopenic Purpura ♦ Proven Benefit ♦ Drug Therapy ♦ Herpes Zoster Infection ♦ Pulse Methylprednisolone ♦ Fulminant Systemic Lupus Erythematosus ♦ Intensive Care Support ♦ Serious Condition ♦ Pseudomonas Septicaemia ♦ English-language Medical Literature ♦ Paediatric Case ♦ Neurological Function ♦ Lupus-related Thrombotic Thrombocytopenic Purpura ♦ 12-year-old Chinese Girl ♦ Poor Outcome ♦ Severe Case ♦ Childhood Systemic Lupus Erythematosus ♦ Pneumocystis Carinii Pneumonia ♦ Rare Complication|
|Abstract||as a rare complication in childhood systemic lupus erythematosus: case report and literature review Thrombotic thrombocytopenic purpura is a rare but serious condition in childhood. It can be idiopathic or a complication of other diseases or drug therapy. We report on a 12-year-old Chinese girl who presented with fulminant systemic lupus erythematosus with progressive renal failure, pancytopenia, and cerebral dysfunction due to thrombotic thrombocytopenic purpura. The patient also had Pneumocystis carinii pneumonia, Pseudomonas septicaemia, and Herpes zoster infections as a result of immunosuppressive treatment. She responded to combined therapy with pulse methylprednisolone, cyclophosphamide, plasmapheresis, and intensive care support, and completely recovered renal and neurological function. A review of the English-language medical literature since 1968 identified 20 other paediatric cases of systemic lupus erythematosus and thrombotic thrombocytopenic purpura. Clinical features, treatment, and outcome of these cases are presented and discussed. Early recognition is important, and although plasmapheresis is not of proven benefit in severe cases of systemic lupus erythematosus, it is life-saving in lupus-related thrombotic thrombocytopenic purpura and must be instituted early to avoid a poor outcome. !"#$%&"'()*+,-./01234&56789:-;<&7 !"#$%&'()*+,-./012%3456NO !"#$%|
|Educational Role||Student ♦ Teacher|
|Age Range||above 22 year|
|Education Level||UG and PG ♦ Career/Technical Study|
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