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Author Hecht, Stephen S.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword P53 Tumor Suppressor Gene ♦ Lung Cancer ♦ Diol Epoxides ♦ Cpg Sequence ♦ Aflatoxin B1 ♦ Previous Study ♦ Activated Carcinogen ♦ Normal Human Bronchial Epithelial Cell ♦ Elegant Work ♦ Present Study ♦ Benzo Chrysene ♦ Reaction Site ♦ P53 Gene ♦ Nontranscribed Strand ♦ Polycyclic Aromatic Hydrocarbon
Abstract The article by Smith et al. (1) in this issue of the Journal extends the elegant work of this group on mapping reaction sites of polycyclic aromatic hydrocarbon (PAH) diol epoxides and other activated carcinogens in the p53 tumor suppressor gene (also known as TP53) (2–4). Previously, these investigators (4) have shown that diol epoxides of benzo[a]pyrene (B[a]PDE) and benzo[g]chrysene, as well as N-acetoxy-2-acetylamino-fluorene and aflatoxin B1 8,9-epoxide, preferentially bind at methylated CpG sequences in the p53 gene. In the present study (1), they mapped the distribution of adducts induced by diol epoxides of five PAH compounds—5-methylchrysene, 6-meth-ylchrysene, chrysene, benzo[g]chrysene, and benzo[c]phenan-threne—in the nontranscribed strand of p53 in normal human bronchial epithelial cells. The results were consistent with those of their previous studies, in that CpG sequences were commonly
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article