Access Restriction

Author Jiang, Zhonghua ♦ Karypis, George
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Historical Medical Condition ♦ Search Space ♦ Novel Measure ♦ New Adverse Reaction ♦ Minimum Improvement Constraint ♦ Interesting Vaccine Adverse Reaction ♦ Mining Frequent Pattern ♦ Generated Pattern ♦ Dense Datasets ♦ Adverse Reaction ♦ Novel Approach ♦ Minimum Dual-lift Constraint ♦ Vaccine Adverse Reaction ♦ Experimental Result ♦ Identifying Medical Condition ♦ Major Constraint ♦ Real World Vaers Database ♦ Dual-lift Measure
Abstract Identifying medical conditions that are correlated with vaccine adverse reactions can not only provide better understanding of how adverse reactions are triggered but also have the potential of detecting new adverse reactions that are otherwise hidden. We formulate this problem as mining frequent patterns with constraints. The major constraint we use is called the minimum dual-lift constraint, where duallift is a novel measure we propose to evaluate correlations in a pattern. We also introduce the notation of minimum improvement constraint to remove redundancy in generated pattern set. We come up with a novel approach to upper bound the dual-lift measure which helps to prune the search space. Experimental results show that our algorithm works significantly better than the baseline on dense datasets. Our algorithm is also tested on the real world VAERS database. Some interesting vaccine adverse reactions identified are presented. 1.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study