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Author Nowotny, Peter ♦ Vierhapper, Heinrich ♦ Waldhausl, Werner
Source CiteSeerX
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Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Abstract SUMMARY The effect of angiotensin II (5, 10, and 20 ng/kg/mln) on blood pressure and on the plasma concentrations of aldosterone was studied in six healthy men with and without the concomitant administration of synthetic human atrial natriuretic peptide given 1) as an i.v. bolus of 25 fig followed by a 6-hour infusion of 25 /xg/hr or 2) as an i.v. bolus of 175 /xg followed by a 6-hour infusion of 100 jig/hr. The pressor effect of angiotensin II (i.e., the rise of mean blood pressure above individual basal levels) remained unchanged during the administration of both doses of human atrial natriuretic peptide. The angiotensin II-induced rise in plasma concentrations of aldosterone (in terms of absolute values) was reduced by human atrial natriuretic peptide during both trials. The rise in plasma concentrations of aldosterone above individual basal concentrations was also reduced during the administration of human atrial natriuretic peptide, although this effect was only marginal during the low dose experiment. These effects of human atrial natriuretic peptide support the contention that its therapeutic impact in hypertensive patients might be mediated in part by a reduction of high aldoste-rone concentrations. (Hypertension 8: 1040-1043, 1986) KEY WORDS • human atrial natriuretic peptide • aldosterone • blood pressure A TRIAL natriuretic peptides inhibit aldosterone
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Institution I. Medizinische Universitatsklinik