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Author Pace, Leonardo ♦ Betocchi, Ro ♦ Franculli, Fabio ♦ Piscione, Federico ♦ Ciarmiello, Andrea ♦ Sullo, Pasquale ♦ Chiariello, Massimo ♦ Salvatore, Marco
Source CiteSeerX
Content type Text
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Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Sector Analysis ♦ Radionuclide Angiography ♦ Left Ventricular Asynchrony ♦ Diastolic Asynchrony ♦ Significant Increase ♦ Standard Deviation ♦ Additional Age-matched Patient ♦ Lv Systolic ♦ Lv Tem Poral Nonuniformity ♦ Phase Value ♦ Fe Male ♦ Age Range 25-60 Yr ♦ Phase Distribution ♦ Time-activ Ity Curve ♦ Reproducibility Study ♦ Phase Image ♦ Heart Rate ♦ Sequen Tial Atrioventricular ♦ Equilibrium Radionuclide Angiography ♦ Optimal Method
Abstract The aim of this study was to assess the optimal method to evaluate asynchrony in equilibrium radionuclide angiography (RNA). Methods: We studied 20 patients (14 males and 6 fe males, age range 25-60 yr) with RNA during atrial and sequen tial atrioventricular (AV) pacing, which increased left ventricular (LV) asynchrony. Both studies were performed at the same heart rate. Asynchrony was assessed either on phase images, by computing the standard deviation of the phase distribution (SD-P) and by sector analysis. Systolic and diastolic asynchrony were evaluated as the coefficient of variation of time to end systole (CV-TES) and time to peak filling rate (CV-TPFR) in four sectors. In addition, phase values were computed on time-activ ity curves from the same sectors, and their standard deviation (SD-Psec) was computed. Results: During atrial pacing SD-P was 32.3°±6.7°and did not change during AV pacing (32.1°± 5.6°,p = n.s.). Both CV-TES and CV-TPFR had a significant increase during AV pacing (from 7.7 % ±3.9 % to 11.5 % ±6.4%, p < 0.01, and from 8.4°±5.8°to 12.9°±6.7°,p < 0.001). AV pacing led to a significant increase in SD-Psec (from 6.3°±4.0° to 12.6°±9.7°,p < 0.05). Moreover, reproducibility was as sessed in 15 additional age-matched patients. The results of the reproducibility study indicate a better repeatability for CV-TES and CV-TPFR. Conclusions: The findings of this study suggest that sector analysis with calculation of indices of LV systolic and diastolic asynchrony is better suited for quantitation of LV tem poral nonuniformity. Key Words: left ventricularasynchrony;radionuclideangiogra phy; phase analysis; sector analysis
Educational Role Student ♦ Teacher
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Educational Use Research
Education Level UG and PG ♦ Career/Technical Study