Access Restriction

Author Survival, Patient
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Heparanase Localization ♦ Tumor Progression ♦ Neck Cancer ♦ Patient Status ♦ Heparanase Upregulation ♦ Patient Outcome ♦ Heparan Sulfate ♦ Primary Human Tumor ♦ Cell Surface ♦ Favorable Outcome ♦ Side Chain ♦ Nuclear Localization ♦ Squamous Cell Carcinoma ♦ Extracellular Matrix ♦ Cellular Invasion ♦ Important Parameter ♦ H Pro-teoglycans ♦ Tumor Grade ♦ Themajor Proteoglycans ♦ Expression Level ♦ Tumor Angiogenesis ♦ Present Study ♦ Reduced Postoperative Sur-vival Rate ♦ Cancer Metas-tasis ♦ Tumor Stage ♦ Cytoplasmic Staining ♦ Heparanase Expression ♦ Nuclear Staining
Abstract Heparanase is an endoglycosidase that specifically cleaves heparan sulfate (HS) side chains of HS pro-teoglycans, themajor proteoglycans in the extracellular matrix and cell surfaces. Traditionally, heparanase ac-tivity was implicated in cellular invasion associated with angiogenesis, inflammation, and cancer metas-tasis. More recently, heparanase upregulation was documented in an increasing number of primary human tumors, correlating with reduced postoperative sur-vival rate and enhanced tumor angiogenesis. In the present study, we examined the expression of hepa-ranase in squamous cell carcinoma of the head and neck by means of immunostaining, and we correlated expression levels with patient outcome. The intensity and extent of heparanase staining correlated with tumor stage (P =.049 and P =.027, respectively), and the extent of staining further correlated with tumor grade (P =.047). Moreover, heparanase expression inversely correlated with patient status at the end of the study (P =.012). Notably, heparanase localization was found to be an important parameter for patient status. Thus, 63 % of patients with nuclear staining, compared to 19 % of patients with cytoplasmic staining (P =.0043), were alive, indicating that nuclear localization of the enzyme predicts a favorable outcome.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study