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Author Leeuw, Karina De ♦ Freire, Beatriz ♦ Smit, Andries J. ♦ Bootsma, Hendrika ♦ Kallenberg, Cees G. ♦ Bijl, Marc
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Endothelial Activation ♦ Ng Ml ♦ Von Willebrand Factor ♦ Disease-related Factor ♦ Intima-media Thickness ♦ Quiescent Disease ♦ Matrix Metalloproteinases ♦ Traditional Risk Factor ♦ Sex-matched Control ♦ Seventy-two Patient ♦ Mg V ♦ Systemic Lupus Erythematosus ♦ Accelerated Atherosclerosis ♦ Tissue Inhibitor ♦ Cardiovascular Risk ♦ Systematic Coronary Risk Evaluation ♦ Vascular Remodeling ♦ Risk Factor ♦ Common Carotid Artery
Abstract Objectives. To determine risk factors of accelerated atherosclerosis in patients with systemic lupus erythematosus (SLE). Methods. Seventy-two patients with quiescent disease and 36 age- and sex-matched controls were included. The intima-media thickness (IMT) of the common carotid artery was determined by ultrasound. Traditional risk factors and disease-related factors were recorded. Cardiovascular risk was estimated using SCORE (systematic coronary risk evaluation). Markers of inflammation, endothelial activation and vascular remodeling (matrix metalloproteinases (MMP-3, MMP-9, and tissue inhibitor of metalloproteinase-1 (TIMP-1)) were determined. Results. IMT was increased in patients (0.67 mm ± 0.13 vs. 0.61 mm ± 0.11, p<0.05). Prevalence of hypertension (33 % vs. 6%, p<0.001), SCORE (2.2 (1.7-4.2) vs. 1.7 (1.3-2.1), p<0.001), as well as parameters of inflammation (CRP 1.8 (0.6-5.8) mg/l vs. 0.6 (0.2-1.0) mg/l, p<0.001) and endothelial activation (VCAM-1 505 (389-683) ng/ml vs. 374 (322-427) ng/ml, p<0.001) and von Willebrand factor (138 (59-208) % vs. 48 (24-
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study