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Author Singhasivanon, Pratap ♦ Imwong, Mallika ♦ White, Nicholas J. ♦ Pukrittayakamee, Sasithon ♦ Stepniewska, Kasia ♦ Day, Nicholas J.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Abstract Abstract. The gametocytocidal and asexual stage activities of eight antimalarial and eight antibiotic-containing regimens were evaluated in 349 adult patients with P. vivax malaria. Gametocytemia was found in 63 % of patients (22% before and 41 % after treatment). The median (range) gametocyte clearance time was 24 hours (range, 2–504 hours) and correlated with asexual parasite clearance time (r 0.52, P < 0.001). Gametocytemia in vivax malaria was more common in patients with admission parasitemia> 10,000/L and after treatment with drugs which have weak antimalarial activity, and was also associated with an increased rate of vivax reappearance (29.4 % versus 14.1%, P 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 2008-01-01