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Author Lin, Dongzi ♦ Lan, Jingfang ♦ Zhang, Zhizhen
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Influenza Virus ♦ Ns1a Protein ♦ Ns1 Protein ♦ Acta Biochimica Et Biophysica Sinica ♦ Effector Domain ♦ Fatal Pneumonia ♦ Avian Influenza Virus ♦ Multiple Organ Failure ♦ Review Briefly ♦ Non-structural Protein ♦ Current Knowledge ♦ Antiviral Response ♦ Rna-binding Domain ♦ Significant Role ♦ Influenza Infection ♦ Multifunctional Protein ♦ Intensive Research ♦ Host Antiviral Response
Abstract Abstract The avian influenza A virus currently prevailing in Asia causes fatal pneumonia and multiple organ failure in birds and humans. Despite intensive research, understanding of the characteristics of influenza A virus that determine its virulence is incomplete. NS1A protein, a non-structural protein of influenza A virus, was reported to contribute to its pathogenicity and virulence. NS1A protein is a multifunctional protein that plays a significant role in resisting the host antiviral response during the influenza infection. This review briefly outlines the current knowledge on the structure and function of the NS1A protein. Key words influenza A virus; NS1A protein; RNA-binding domain; effector domain; dimer; resistance; antiviral response
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Publisher Date 2007-01-01