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Author Amaral, L. L. F. Do ♦ Ferreira, R. M. ♦ Ferreira, N. P. F. D. ♦ Mendonça, R. A. ♦ Marussi, V. H. R. ♦ Medeiros, J. D.
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Case Report ♦ Prop-1 Mutation ♦ Pituitary Enlargement ♦ Pituitary Hormone Deficiency ♦ Distinct Mr Imaging Pattern ♦ Slight Hyperintensity ♦ Single Transcriptional Factor ♦ Anterior Pituitary Lobe ♦ Transcrip-tion Factor ♦ Prop-1 Gene ♦ Striking Hypointensity ♦ Identical Finding ♦ Pituitary Cell ♦ Follicle-stimulating Hormone ♦ Enlarged Adenohypophysis ♦ Essential Role ♦ Tocombined Pituitary Hormone Deficiency ♦ Thyroid-stimulating Hormone ♦ Hormonal Replacement ♦ T1-weighted Image ♦ Growth Hormone ♦ Initial Pituitary Mr Imaging Examination ♦ Prop-1 Defect ♦ Follow-up Mr Imaging ♦ T2-weighted Image
Abstract of 2 siblings with PROP-1 mutations whom we observed longitudinally. Their initial pituitary MR imaging examinations showed identical findings: an enlarged adenohypophysis, with striking hypointensity on T2-weighted images and slight hyperintensity on T1-weighted images. In one of the children, the follow-up MR imaging obtained 3 years after hormonal replacement revealed a decrease in the size of the anterior pituitary lobe. Disturbances of single transcriptional factors can lead tocombined pituitary hormone deficiency (CPHD). The Prophet of Pit-1 (PROP-1) protein is one of these transcrip-tion factors.1,2 The PROP-1 gene plays an essential role in the evolution of pituitary cells secreting growth hormone (GH), prolactin, thyroid-stimulating hormone (TSH), leuteinizing hormone, and follicle-stimulating hormone.1,3,4 It accounts for approximately 50 % of genetically determined CPHD.5,6 We report the cases of 2 siblings with PROP-1 defects whom we observed longitudinally. Case Reports
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study