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Author Lee, Yue-Yuan ♦ Lin, Long-Yau
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Cyclopia Visualized ♦ Three-dimensional Prenatal Ultrasound ♦ Report Holoprosencephaly ♦ Prenatal U ♦ Chang Gung Med ♦ Normal Karyotype ♦ Proper Counseling ♦ Ges-tational Age ♦ Facial Abnormality ♦ Fetal Face ♦ Sonographic Diagnosis ♦ Transabdominal U ♦ Addi-tional Diagnostic Image ♦ Visible Midline Structure ♦ Prostaglandin Induction ♦ Intracranial Finding ♦ Fused Thalamus ♦ Postmortem Examination ♦ Informed Consent ♦ Chromosome Study ♦ Alobar Holoprosencephaly
Abstract We report on the ultrasound (US) detection of holoprosencephaly with cyclopia at a ges-tational age of 16 weeks. The sonographic diagnosis was based on the intracranial finding of fused thalami with no visible midline structures and facial abnormalities, including cyclopia and proboscis. We evaluated the fetal face by 3-dimensional (3D) transabdominal US and were able to identify the cyclopia below the proboscis. These findings are charac-teristic of alobar holoprosencephaly. With the informed consent of the patient, the pregnancy was terminated by prostaglandin induction after proper counseling. Chromosome study of the abortus revealed a normal karyotype (46, XY). Postmortem examination of the abortus confirmed the presence of cyclopia and a proboscis. The use of 3D prenatal US made addi-tional diagnostic images possible. (Chang Gung Med J 2002;25:207-10)
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study