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Author Cao, Hui ♦ Wen, Jun ♦ Nie, Ya Li ♦ Xu, Ming
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Diallyl Disulfide ♦ Allium Sativum ♦ Apoptotic Cell ♦ Oil-soluble Organosulfur Compound ♦ Concentration-dependent Manner ♦ Transient Increase ♦ G2 M-phase Cell ♦ Cell Cycle ♦ G2 M-phase Block ♦ Mapk Phosphorylation ♦ Cell Viability ♦ Potent Increase
Abstract Abstract. This study was undertaken to elucidate the effect of diallyl disulfide from Allium sativum, an oil-soluble organosulfur compound found in garlic, in suppressing human non-small cell lung carcinoma H1299 cells. A potent increase in apoptotic cells has accompanied 1) a decrease in cell viability, 2) an increase of the fraction of G2/M-phase cells by up to 48.80 %, and 3) a transient increase of the phospho-p42/44 (phosphorylated p42/44 MAPK) in a time- and concentration-dependent manner. These results indicated that diallyl disulfide could induce apoptosis in human non-small cell lung carcinoma H1299 cells via, at least partly, G2/M-phase block of the cell cycle, related to a rise in MAPK phosphorylation.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article