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Author Pers, Yves-Marie ♦ Jorgensen, Christian
Source CiteSeerX
Content type Text
File Format PDF
Subject Domain (in DDC) Computer science, information & general works ♦ Data processing & computer science
Subject Keyword Therapeutic Outlook ♦ Mesenchymal Stromal Cell ♦ Rheumatic Disease ♦ Paracrine Mediator ♦ Stem Cell Therapy ♦ Available Data ♦ Clinical Efficacy ♦ Degenerative Rheumatic Disease ♦ Double-blind Trial ♦ Mesenchymal Stem Cell ♦ Recent Progress ♦ Clinical Application ♦ Functional Property ♦ Cell-based Clinical Therapy ♦ Adult Stem Cell ♦ Preclinical Model
Abstract Abstract: Multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) are adult stem cells exhibiting functional properties that have opened the way for cell-based clinical therapies. MSCs have been reported to exhibit immunosuppressive as well as healing properties, improving angiogenesis and preventing apoptosis or fibrosis through the secretion of paracrine mediators. This review summarizes recent progress on the clinical application of stem cells therapy in some inflammatory and degenerative rheumatic diseases. To date, most of the available data have been obtained in preclinical models and clinical efficacy needs to be evaluated through controlled randomized double-blind trials.
Educational Role Student ♦ Teacher
Age Range above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Article
Publisher Date 2013-01-01