|Author||Wolff, S. ♦ Arutyunyan, R.|
|Source||United States Department of Energy Office of Scientific and Technical Information|
|Subject Keyword||RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT. ♦ LYMPHOCYTES ♦ CHROMOSOMAL ABERRATIONS ♦ RADIOPROTECTIVE SUBSTANCES ♦ BIOLOGICAL EFFECTS ♦ ANTINEOPLASTIC DRUGS ♦ CELL CULTURES ♦ CELL CYCLE ♦ MAN ♦ MUTAGENESIS ♦ MUTAGENS ♦ MUTATION FREQUENCY ♦ ANIMAL CELLS ♦ ANIMALS ♦ BIOLOGICAL MATERIALS ♦ BLOOD ♦ BLOOD CELLS ♦ BODY FLUIDS ♦ CONNECTIVE TISSUE CELLS ♦ DRUGS ♦ LEUKOCYTES ♦ MAMMALS ♦ MATERIALS ♦ MUTATIONS ♦ PRIMATES ♦ RESPONSE MODIFYING FACTORS ♦ SOMATIC CELLS ♦ VERTEBRATES ♦ Chemicals Metabolism & Toxicology- Cells- (-1987) ♦ Radiation Effects on Cells- External Source- (-1987)|
|Abstract||Antimutagenic radioprotective compounds have been reported to decrease the yield of chemically induced chromosome aberrations even when administered long before the chemical mutagen thio-TEPA. Because thio-TEPA can induce aberrations in all parts of the cell cycle, it seemed likely that the apparent decrease in aberrations was the result of an effect of the antimutagen on the progression of cells through the cell cycle so that cells treated in the more sensitive stage would be scored. To test this possibility human lymphocytes were treated with the protective compound WR2721 and then thio-TEPA. The cells were grown in the presence of 5-bromodeoxyuridine, which allows the definitive determination of metaphases from cells that divided once, twice, or three times after treatment. The yield of aberrations observed in first division cells was the same whether or not the protector was present. A decrease in aberration yields appeared only in rapidly cyling cells that were in the second division at the time of fixation. Labeling experiments showed that in this rapidly dividing population fewer of the metaphase cells had been in G/sub 2/ when thio-TEPA was added. The results indicate that part of the decrease in aberration yields obtained by treatment with an antimutagen several hours before the addition of a mutagen is an artifact of cell selection.|
|Learning Resource Type||Article|
|Publisher Place||United States|
|Organization||Univ. of California, San Francisco|
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