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Author Boatta, Emanuele ♦ Jahn, Christine ♦ Canuet, Matthieu ♦ Garnon, Julien ♦ Ramamurthy, Nitin ♦ Cazzato, Roberto Luigi ♦ Gangi, Afshin
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword RADIOLOGY AND NUCLEAR MEDICINE ♦ ARTERIES ♦ BUBBLES ♦ BYPASSES ♦ CLOSURES ♦ COMPUTERIZED TOMOGRAPHY ♦ DIAGNOSIS ♦ MALFORMATIONS ♦ PATIENTS ♦ PERMEABILITY ♦ SYMPTOMS ♦ VASCULAR DISEASES
Abstract AIMTo report our preliminary experience using a Micro Vascular Plug (MVP) deployed through a 2.8Fr micro-catheter for the treatment of pulmonary arteriovenous malformations (PAVMs) in a cohort of patients affected by Hereditary Haemorrhagic Telangiectasia (HHT).Materials and MethodsFour consecutive female patients (mean age 38.0 years; range 25–55 years) with PAVMs diagnosed on echocardiogram/bubble test and contrast-enhanced CT (CECT) underwent MVP embolization. One patient was symptomatic with recent transient ischaemic attack. Follow-up was undertaken at 1-month post-procedure with CECT to assess PAVMs permeability and MVP positioning and at 1-, 6-, and 12-month post-procedure, with echocardiography/bubble test and standard neurological history, to confirm absence of right-to-left shunts and recurrent symptoms.ResultsEight PAVMs were treated in 4 patients over 5 interventional sessions (mean 1.6 PAVMs per session). All PAVMs were simple, with mean feeding artery diameter of 4.25 mm. Eight 6.5 mm MVPs were deployed in total (one per lesion). Technical success was 100%. Mean procedural time and patient dose per session were 70 min (range 40–70 min) and 53418 mGy.cm{sup 2} (range 6113–101628 mGy.cm{sup 2}), respectively. No signs of reperfusion neither of MPV migration were noted at 1-month CECT follow-up. At early follow-up (mean 3.75 months; range 1–12 months), clinical success was 100% with no evidence of recurrent right-to-left shunt, and no neurological symptoms. No immediate or late complications were observed.ConclusionsMVP embolization of PAVMs appears technically feasible, safe, and effective at early follow-up. Further prospective studies are required to confirm long-term safety and efficacy of this promising technique.
ISSN 01741551
Educational Use Research
Learning Resource Type Article
Publisher Date 2017-02-15
Publisher Place United States
Journal Cardiovascular and Interventional Radiology
Volume Number 40
Issue Number 2


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