Thumbnail
Access Restriction
Open

Author Burniston, Jatin G. ♦ Lisboa, Paulo J. ♦ Shepherd, Sam O. ♦ Srisawat, Kanchana
Source Directory of Open Access Journals (DOAJ)
Content type Text
Publisher MDPI AG
File Format PDF
Date Created 2017-11-24
Copyright Year ©2017
Language English
Subject Domain (in LCC) QR1-502
Subject Keyword Systematic review (SR) ♦ Type 2 diabetes ♦ Meta-analysis (MA) ♦ Protein abundance ♦ Science ♦ Microbiology ♦ Mass spectrometry ♦ High intensity exercise ♦ Insulin resistance ♦ Obese
Abstract We performed a systematic review and meta-analysis of proteomics literature that reports human skeletal muscle responses in the context of either pathological decline associated with obesity/T2DM and physiological adaptations to exercise training. Literature was collected from PubMed and DOAJ databases following PRISMA guidelines using the search terms ‘proteom*’, and ‘skeletal muscle’ combined with either ‘obesity, insulin resistance, diabetes, impaired glucose tolerance’ or ‘exercise, training’. Eleven studies were included in the systematic review, and meta-analysis was performed on a sub-set (four studies) of the reviewed literature that reported the necessary primary data. The majority of proteins (n = 73) more abundant in the muscle of obese/T2DM individuals were unique to this group and not reported to be responsive to exercise training. The main response of skeletal muscle to exercise training was a greater abundance of proteins of the mitochondrial electron transport chain, tricarboxylic acid cycle and mitochondrial respiratory chain complex I assembly. In total, five proteins were less abundant in muscle of obese/T2DM individuals and were also reported to be more abundant in the muscle of endurance-trained individuals, suggesting one of the major mechanisms of exercise-induced protection against the deleterious effects of obesity/T2DM occurs at complex I of the electron transport chain.
ISSN 22277382
Age Range 18 to 22 years ♦ above 22 year
Educational Use Research
Education Level UG and PG ♦ Career/Technical Study
Learning Resource Type Review
Publisher Date 2017-11-01
e-ISSN 22277382
Journal Proteomes
Volume Number 5
Issue Number 4
Starting Page 30


Source: Directory of Open Access Journals (DOAJ)