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Author Li, Dongdong ♦ Zhang, Yuping ♦ Zhou, Bingbing
Source United States Department of Energy Office of Scientific and Technical Information
Content type Text
Language English
Subject Keyword INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY ♦ AGGLOMERATION ♦ CATIONS ♦ COMPARATIVE EVALUATIONS ♦ COPRECIPITATION ♦ DOXORUBICIN ♦ IRRADIATION ♦ PH VALUE ♦ ROTATION ♦ STYRENE ♦ ZIRCONIUM PHOSPHATES ♦ ZIRCONIUM PHOSPHIDES
Abstract Aggregation-induced emission (AIE) luminogen, quaternary tetraphenylethene cation (TPEN), was successfully incorporated into layered α-zirconium phosphate (α-ZrP) by using co-precipitation method to form inorganic–organic hybrid materials. The obtained materials show the characteristic hexagonal platelet shape with the interlayer distance did not reveal significant difference compared with pure α-ZrP. In addition, the obtained hybrid materials emit strong blue emission centered at 476 nm in aqueous media due to the electrostatic interactions of TPEN with the anionic framework of α-ZrP, which largely restrict their intramolecular rotation. More importantly, the materials provide a pH dependent release of doxorubicin (DOX), suggesting that AIE luminogen functionalized α-ZrP may be used as an imaging guided and pH-responsive delivery system for targeting therapy. - Graphical abstract: AIE luminogen was successfully incorporated into layered α-zirconium phosphate by a co-precipitation method to form inorganic–organic hybrid materials, showing a pH dependent release of DOX. - Highlights: • AIE luminogen cation was incorporated into layered α-ZrP by co-precipitation method. • The obtained material emits strong blue emission upon UV irradiation. • The material exhibits pH dependent release of DOX. • The AIE functionalized α-ZrP has potential applications in imaging guided therapy.
ISSN 00224596
Educational Use Research
Learning Resource Type Article
Publisher Date 2015-05-15
Publisher Place United States
Journal Journal of Solid State Chemistry
Volume Number 225


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